A therapeutic opportunity in melanoma: ErbB4 makes a mark on skin.
نویسنده
چکیده
Malignant melanomas are aggressive tumors that are largely refractory to conventional drug therapies. A recent study reported in Nature Genetics identified mutationally activated ErbB4 alleles in 20% of cases. These tumor cells exhibit ErbB4 dependency, suggesting that ErbB4 kinase inhibition may constitute an effective therapeutic strategy in this setting.
منابع مشابه
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عنوان ژورنال:
- Cancer cell
دوره 16 4 شماره
صفحات -
تاریخ انتشار 2009